Sad in the spring? Allergy-mood link is real       By Elizabeth Landau, CNN  Updated 5:53 AM ET, Fri March 23, 2018

Sad in the spring? Allergy-mood link is real By Elizabeth Landau, CNN Updated 5:53 AM ET, Fri March 23, 2018

You know spring has sprung when hundreds of people daily turn to Twitter to vent about their itchy eyes, dripping nose and uncontrollable sneezing and coughing.

Seasonal allergies, which affect about 36 million Americans, aren't just an annoyance; many doctors agree that there is a real connection between allergies and mood.

"'Cranky' is really the best word for it," said Katie Ingram, 30, of Alexandria, Virginia, a triathlete who has seasonal allergies. "I take a lot of medication for it, and that makes me sleepy. And I can't do a lot of the things that I like to do outside, so that makes me cranky. ... The wheezing part of it makes me feel tired."

    In some people, such annoyances are more serious. Research has shown that there is about a 50% increase in the risk for depression in a person suffering allergies, and if you've been seen by an allergist, that about triples the likelihood of having depression, said Dr. Paul Marshall, neuropsychologist at Hennepin County Medical Center in Minneapolis.

    hose are correlations found in scientific studies, but they don't show that allergies cause clinical depression. In practice, allergy-connected mood changes usually boil down to mild depressive symptoms, like feeling sad, lethargic and fatigued, Marshall said. Some people say they're more likely to cry during the allergy season. Allergies could make symptoms even worse in a person with clinical depression, experts say.

    "It's important for people to understand that experiencing allergies can affect their mood," Marshall said.

    That's not to say that all people with allergies have depression or that all people with depression have allergies. But experiencing allergic reactions does seem to be a risk factor for developing depression -- not necessarily the emotional side of the condition but more physiological symptoms such as low energy.

    But is all of this in spite of the use of antihistamines or because of it? And is it the actual allergic reaction that causes these symptoms or just the sleep disturbances and general discomfort?

    An allergic reaction is an immune response that releases cytokines, protein molecules used in communication between cells. When they signal the brain, they induce the feelings of sickness, or being "mentally drained," that often accompany the flu. This cytokine release isn't as powerful in allergies, but it's still present, Marshall said.

    A 2002 study Marshall led, published in the journal Psychosomatic Medicine, found that allergic reactions to ragweed pollen cause "significant fatigue and mood changes" in at least some patients. Research that Marshall collaborated on in 2000 found that such reactions could cause slowed speed of cognitive processing. 

    Dr. Teodor Postolache at the University of Maryland led a review published in 2008 of the association between suicidal indicators and allergies. Postolache's group noted a peak in suicide rates from April to June and the dramatic environmental change of pollen that occurs during that time. The researchers found correlations between depression measurements and allergy symptoms in relation to the seasonal severity of tree pollen. In women, the association is stronger between allergy, depression and suicide than in men, perhaps because allergy and depression are more common in women anyway.

    Postolache's group has also explored cytokines that may be involved in triggering fatigue, hypothesizing that the allergic reaction is the direct biological cause of low mood.

    This parallels what happens when stress gets you down too, Marshall says.

    What to do?

    Several types of medications are available to treat allergy symptoms, including pills, liquids, inhalers, nasal sprays, eye drops, skin creams and shots. Most work by modulating the body's response to the perpetrating allergen, either by blocking histamine -- a chemical released by the immune system during an allergic reaction -- or by reducing inflammation through the use of steroids, according to the Mayo Clinic.

    Some are also combined with a decongestant, such as pseudoephedrine, to relieve nasal and sinus congestion.

    Many allergy sufferers also find relief in over-the-counter products such as the neti pot and other nasal rinses for sinus problems.

    But the only way to get more complete, prolonged relief from allergies is to undergo desensitization or "allergy shots," Overholt said. After an initial test to see what specific plants affect the patient, a doctor would administer small doses of the offending pollen or other substance under the skin over the course of three to five years.

    At the end of that time, protection from allergies lasts another three to five years on average, with some people coming out allergy-free for life and others getting relief for only a year or two.

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